Molecular Aspects of Varicella-Zoster Virus Latency
نویسندگان
چکیده
منابع مشابه
Key issues in varicella-zoster virus latency.
The molecular mechanisms by which varicella-zoster virus (VZV) causes a latent infection in human trigeminal and spinal ganglia are not well understood. It is known that VZV establishes latency in ganglia following the primary infection causing varicella (chickenpox), and that the virus may reactivate after years of dormancy to produce herpes zoster (shingles). Two key issues have been the cell...
متن کاملMolecular biology of varicella zoster virus.
Varicella–zoster virus (VZV), also known as human herpesvirus 3 (HHV3) belongs to the herpesvirus family (Herpesviridae). This classification is based on the morphological characteristics of the virus and its physical and chemical properties. The Herpesvirus Study Group of the International Committee on the Taxonomy of Viruses (ICTV) divided the members of this family into three subfamilies: Al...
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Varicella zoster virus (VZV) is the herpesvirus which causes the childhood disease varicella, also known as chickenpox, and the adult disease herpes zoster, also known as shingles. These distinct diseases are separated by a lengthy period of latency, often lasting decades, in which the virus resides within the ganglia of the host. VZV latency and reactivation from it have, for the most part, be...
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متن کاملVaricella zoster virus.
Because of its ability to produce two clinically distinct disease entities (chickenpox and shingles), varicella zoster virus (VZV) is an unusual etiologic agent. Although in the past viral exanthems were mostly only of academic interest to the practitioner, the development of antiviral agents and the newly approved varicella (OKA) vaccine have increased the clinical significance. Also, with the...
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ژورنال
عنوان ژورنال: Viruses
سال: 2018
ISSN: 1999-4915
DOI: 10.3390/v10070349